IBS DIY FMT, huh?
I work in the biopharma industry so naturally I've been on the other side of the drug business. I can tell you the entire process of how to discover, and after a fortunate 5-10 years, market a drug. But, I'm only now exploring the consumer side.
All drugs, and drug delivery methods, are tested in controlled environments prior to being marketed in our regulated trade economy. IBS therapies don't widely exist yet, but there are some being tested now!
The leading potential solution for IBS is fecal matter transplant (FMT). It sounds like what it is - transplantation of fecal bacteria from a healthy individual into a recipient. There have been studies that show FMT as the solution for individuals with Clostridium difficile ("C. diff") bacterial infection.
IBS is understood as a bacterial imbalance of the gut... not quite an infection. Five years ago my GI doctor explained to me that IBS is usually a result of an event or disturbance of the microbiome. My "event" occurred when I visited Brazil in 2012 and drank from a waterfall, drank non-bottled water, and ate street food such as steamed corn on the cob. Other causes can be from over-use of antibiotics that can kill off "good" bacteria in the gut, which leaves room for proliferation of "bad" bacteria. Some antibiotics do not specifically target a species of bacteria, but many species.
I just stumbled upon a great IBS Support Group online. They posted:
I've looked into DIY procedures for FMT and had discomfort in the uncontrolled environment... among other things! 💩 If anyone has the guts (pun intended) to DIY, I found The Power of Poop's procedure to be comprehensive.
I decided for a more controlled environment. ClinicalTrials.gov is the place to find therapies under evaluation by drug sponsors. I typed in IBS in the field for Condition/Disease and am exploring enrollment into a trial. Wish me luck.
✌💛😁 Christine Ann
All drugs, and drug delivery methods, are tested in controlled environments prior to being marketed in our regulated trade economy. IBS therapies don't widely exist yet, but there are some being tested now!
The leading potential solution for IBS is fecal matter transplant (FMT). It sounds like what it is - transplantation of fecal bacteria from a healthy individual into a recipient. There have been studies that show FMT as the solution for individuals with Clostridium difficile ("C. diff") bacterial infection.
IBS is understood as a bacterial imbalance of the gut... not quite an infection. Five years ago my GI doctor explained to me that IBS is usually a result of an event or disturbance of the microbiome. My "event" occurred when I visited Brazil in 2012 and drank from a waterfall, drank non-bottled water, and ate street food such as steamed corn on the cob. Other causes can be from over-use of antibiotics that can kill off "good" bacteria in the gut, which leaves room for proliferation of "bad" bacteria. Some antibiotics do not specifically target a species of bacteria, but many species.
I just stumbled upon a great IBS Support Group online. They posted:
In the spring of 2013, the United States Food and Drug Administration (FDA) stated that it would require FMT products to be administered under an Investigational New Drug Application (“IND”). FDA reasoned that FMT was a biologic and that requiring INDs would help to protect patients by standardizing therapy, adding oversight, and encouraging the development of reliable products.
Advocates of FMT reacted to FDA’s new requirements by highlighting the time and cost of submitting an IND. Moreover, they emphasized that requiring INDs could lead patients to resort to do-it-yourself procedures. Only a month later, FDA made an informal statement that it would exercise enforcement discretion and allow practitioners to conduct FMT procedures without INDs.
I've looked into DIY procedures for FMT and had discomfort in the uncontrolled environment... among other things! 💩 If anyone has the guts (pun intended) to DIY, I found The Power of Poop's procedure to be comprehensive.
I decided for a more controlled environment. ClinicalTrials.gov is the place to find therapies under evaluation by drug sponsors. I typed in IBS in the field for Condition/Disease and am exploring enrollment into a trial. Wish me luck.
✌💛😁 Christine Ann
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